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The main features of initial epithelial injury are mucociliary dysfunction, goblet cell hyperplasia, and disruption of tight junction proteins, changes that together impair mucociliary clearance and compromise barrier integrity ( Expansion Phase Immune cell recruitment mediator release critical pathway activation transition to senescence Small airway inflammation is induced by chronic exposure to cigarette smoke and atmospheric particulate matter

The method used to prepare missing summary statistics of age range was to report the mean age